5 Simple Techniques For https://www.ceesdekker.net
5 Simple Techniques For https://www.ceesdekker.net
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Working with solitary-molecule optical and AFM imaging and force-spectroscopy techniques, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study pursuits incorporate:
Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular types with recombination functionality.
[Laughs] ‘It absolutely was undoubtedly a terrific possibility! At enough time, I used to be properly mindful that it could go Incorrect and that I could become significantly less thriving, but I just overlooked that. Curiosity has constantly been my strongest driving power. And fortuitously it all labored out.’
Because 2000, Dekker has shifted the principle focus of his perform toward biophysics where he scientific studies the Houses of one biomolecules and cells using the equipment of nanotechnology. This alteration of field was driven by his fascination to the amazing performing of Organic molecular structures, along with because of the long-phrase point of view a large number of attention-grabbing discoveries may be anticipated In this particular subject.[five] Present-day strains of research in his biophysics group are within the areas of:[6]
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In the years next these discoveries, my exploration passions shifted to biophysics and nanobiology, and I became less linked to the event of nanotube electronics. The main focus https://www.ceesdekker.net of many scientists in the sector also shifted to graphene (exactly where, funnily enough, the main graphene ribbons were called ‘nanotubes which might be Lower open together their size’) following the invention of the two-dimensional material in 2004.
We shape bacteria into sorts that deviate from their purely natural phenotype. Precisely, I'll demonstrate our capability to shape Are living E. coli micro organism into novel designs including rectangles, squares, triangles and circles.
2000, discovery that nanotubes can have extraordinary significant recent densities; fixed the controversial problem of electronic transportation by DNA molecules by measurements of insulating behavior at the single molecule level; and demonstration of an AFM procedure for one-molecule manipulation of nanotubes
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‘The fantastically refined way where aspects in nature function hardly ever ceases to amaze me. If we clear up the puzzle of how daily life came into being, I hope that my amazement with the complexity of creation will have amplified and with it my awe to the greatness in the Creator.’
An built-in microfluidic System for quantifying drug permeation across biomimetic vesicle membranes
1999, initially measurement from the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for any new Luttinger description of interacting electrons in nanotubes
2005, discovery with the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of prolonged-range conformational alterations in Mre11/DNA maintenance complexes; and very first drive measurements on a DNA molecule in the nanopore
At last, I will briefly sketch a few of our Tips to check out the making of artificial cells, specially our to start with ways to determine artificial mobile division.